Brandy M. Sreenilayam
My research focuses on purifying a specific protein of interest, setting up conditions to grow protein crystals and solving the crystal structure of the protein. Obtaining the crystal structure of any protein speeds up the process in which therapeutic drugs are designed. Currently, we are interested in a protein named LGN... Further details...
Representative Publications (formerly published as B. Barren)
B. Barren, L. Gakhar, H. Muradov, S. Ramaswamy, N.O. Artemyev, “Structural Basis of Phosphodiesterase 6 Inhibition by the gamma-subunit.”, Eur. Molec. Biol. Organiz. J. 2009, 28, 3613-3622.
B. Barren, N.O. Artemyev, “Mechanisms of dominant negative G-protein alpha subunits” , J. Neurosci. Res., 2007, 85, 3505-3514.
B. Barren, M. Natochin, N.O. Artemyev, “Mutation R238E in transducin-alpha yields a GTPase and effector-deficient, but not dominant negative, G-protein alpha-subunit”, Molec. Vision 2006, 12, 492-498.
M. Natochin, B. Barren, N.O. Artemyev, “Dominant negative mutants of transducin-alpha that block activated receptor”, Biochemistry, 2006, 45, 6488-6494.
M. Natochin, T.N. Campbell, B. Barren, L.C. Miller, S Hameed, N.O. Artemyev, J.E. Braun, “Characterization of the G alpha(s) regulator cysteine string protein”, J. Biol. Chem., 2005, 280, 30236-30241.
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