September 26, 2013
St. Fisher College
Synthesis and Characterization of New Chiral Ionic Liquids and
Evaluation of Their Chiral Recognition Abilities
Chiral ionic liquids (CILs) are attractive for their potential applications in chiral analysis. The current increase in ionic liquids (ILs) derived from amino acids that are chiral, ‘green’, biocompatible and less toxic has also created interest in CILs. My research is focused on the synthesis, characterization and evaluation of the chiral recognition ability of new amino acid-based ILs for chiral discrimination. This includes investigations of their use as chiral selectors and chiral stationary phases in gas chromatography. The project involves synthesizing new amino acid ester based ILs using an anion metathesis reaction involving amino acid ester chlorides and a lithium ion electrolyte. The resultants CILs are analyzed for purity using NMR and their physico-chemical and spectroscopic properties determined using various spectroscopic techniques. The ability of the CILs to discriminate between enantiomers is determined using fluorescence spectroscopy with chiral fluorescent analytes.