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Chemistry and Biochemistry Seminar

September 18, 2014
Smith Hall,
Room 114, 12:30 p.m.

*Pre-seminar reception at 12:15 a.m.

Markus Seeliger

Stony Brook University School of Medicine Department of Pharmacological Sciences
Stony Brook, NY

Synthesis and Development of Specific Enzyme Inhibitors

Our lab studies the interaction of small molecule ligands with their protein targets using X-ray crystallography, NMR and molecular dynamics simulations. We aim to help aspiring small molecules to become drugs and we use small molecules as tools to study enzyme regulation. In collaboration with medicinal chemists we have characterized the mechanism of action of class of cyclic peptides that exhibit unusually high specificity for their drug targets: the viral proto-oncogene Src kinase and the insulin degrading enzyme IDE. Src is an attractive drug target in cancer therapy and IDE is a new drug target for the therapy of type-2 diabetes. The lecture is aimed specifically at undergraduate students who are considering a career in basic science research or research-related healthcare.