October 31, 2013
Chemistry Department, Wayne State University
From Graduate School to Teaching Chemistry: Challenges and Rewards
Synthesis of N-Acetyl And C-Tert-Butyl Natural Amino Acid Substrates That Mimic Residues Of Polypeptides And Their Reactivity With [FeIV(O)(N4Py)]2+: Kinetic And Mechanistic Investigations
Part I - Perusing a graduate degree in chemistry can be both challenging and rewarding. There are many important decisions to make that will shape the overall graduate experience, including choosing the right advisor. Share the speakerís experience on her journey from The College at Brockport to teaching at Wayne State University and the differences between teaching at large universities and primarily undergraduate institutions.
Part II. Substrates derived from Gln, Asn, Ile, Cys. Phe and Tyr were synthesized to mimic amino acid residues. These substrates were reacted with [FeIV(O)(N4Py)]2+ under pseudo-first order conditions. The mechanisms for the reactions of the most reactive substrates were investigated. Electron-transfer proton-transfer and hydrogen atom transfer mechanisms are suggested for the substrates derived from Cys and Tyr, respectively, for their reaction with [FeIV(O)(N4Py)]2+. An electrophilic aromatic substitution mechanism is suggested for the mechanism of the reaction of the substrate derived from Phe with [FeIV(O)(N4Py)]2+.