February 19, 2015
Mr. Michael Rogerson
The purpose of these studies was to evaluate how well chloroquine and its analogs worked in conjunction with protein kinase B inhibitors in killing cancer cells. These studies have determined that chloroquine and its analogs having an affinity for cancer cells which in turn leads to a targeting of the cancer cell to a second cancer drug. Targeting therapies like this could lead to significant improvements in cancer treatment and controlling the growth of cancer cells. Targeting of cancer drugs have been shown to reduce the concentrations required to induce cell killing, which could reduce the side effects of therapies. This mechanism was evaluated utilizing various human breast cancer cell lines. Results yielded from the tests show that chloroquine analog 5 works more effectively with protein kinase B inhibitors 8 and 9. The combination of analog 5 with inhibitors 8 and 9 appear to have more cancer specificity. Analysis of the structures of chloroquine and each analog reveals that the 4-aminoquinoline scaffold plays a significant role in enhancement of cell killing.
Mr. Shane Colvin
The Chemistry of Unhopped Wort
Microbreweries are on the rise and becoming very popular. Owners tend to focus on quality over quantity with their product. Recently, research was conducted in attempt to determine the entire flavor profile of a specific beer style, pilsner, and how varying the brewing conditions may affect the concentrations of these volatiles. GC-MS was used to separate and identify the compounds present in the wort and condensate, resulting in the identification of a total of 118 individual compounds including (2E)-2-phenyl-2-octenal, a compound not yet reported in the literature. The results of this research may help thousands of breweries across the nation to optimize brewing conditions for enhancing the quality of their products.