Gastrointestinal (GI) motility is essential for the efficient digestion and absorption of nutrients in higher vertebrates, including humans. Observed GI systems require smooth muscle, enteric neurons, and interstitial cells of Cajal (ICC) in conserved anatomical organization to induce proper motility. ICC regulate GI contractile strength and frequency in human, murine , and guinea pig models. ICC are identified using Kit immunoreactivity. The cellular and molecular bases of GI motility are limited due to the nature of current model systems. The optical transparency of the zebrafish larvae and the ability to identify novel genes via a forward-genetic approach contribute to the utility of the zebrafish as model for GI motility. This investigation aims will determine the anatomical positioning of cells with Kit-like immunoreactivity relative to smooth muscle and enteric neurons in the zebrafish GI tract. Anatomical position of cells with Kit-like immunoreactivity will contribute to identification of these cells as ICC, and to the development of a zebrafish based model for GI motility.
|Presenters:||Stephanie Gross (Undergraduate Student)
Stacey Hess (Graduate Student)
Scott Leddon (Graduate Student)
Kyle Leonard (Undergraduate Student)
Adam Rich (Faculty)
|Time:||10 am (Session I)|