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Scholars Day 2006, Wednesday, April 12

Computational Characterization Study of 5 Untranslated Regions of Human mRNA

Mammalian mRNAs are translated with different efficiency. In addition, efficiency of mRNA translation can be affected by physiologic and pathophysiologic conditions. Factors responsible for efficiency of mRNA have been studied to some extent in vitro, but there is no unifying model that would explain efficiency of mRNA translation on a genome-wide scale. This presentation is about a project involving the creation of bio-informatic tools required for such an undertaking and carrying out preliminary studies to validate the computational tools. The presentation also introduces a software package that takes into consideration the presence of upstream AUG codons and free energy to determine the intrinsic efficiency of mRNA translation under different conditions - normal physiology, when rate of translation is increased such as it occurs in certain cancers or when rate of translation is decreased such as it occurs when cells are under the stress.

Presenter: Stefan Christov (Undergraduate Student)
Topic: Computational Science
Location: 204 Holmes
Time: 2:30 pm (Session IV)