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Scholars Day 2006, Wednesday, April 12

BOTOX®: A Derivative of Clostridium botulinum

Botox® is the number one choice for non-surgical cosmetic enhancement in the United States, according to the American Society for Aesthetic Plastic Surgery. However, Botox® is more than medicine’s solution to defying the natural aging process. The role of Botox® within plastic surgery, including physician and patient responsibilities, will be introduced in this Honors thesis paper. The biochemical structure of Botox®, as a derivative of the botulinum neurotoxin type A protein complex secreted by Clostridium botulinum, will be differentiated from that of its botulism poisoning counterpart. Botox® induces chemodenervation at the neuromuscular junction through the inhibition of acetylcholine release; the specific mechanism through which this process occurs will also be presented. An overview of clinical Botox® usage, for both cosmetic and therapeutic purposes, will be discussed as well.

Presenter: Elizabeth Delorme (Undergraduate Student)
Topic: Biological Sciences
Location: 216 Hartwell
Time: 1:15 pm (Session III)