Notch, N, and enhancer of rudimentary, e(r), are two highly conserved genes found in eukaryotes as diverse as humans and fruit flies. N encodes a transmembrane protein that is cleaved and transported to the nucleus, where it activates transcription as part of the Notch-Delta signal transduction pathway. This pathway directs cell differentiation in both mammals and insects. In the fruit fly, Drosophila melanogaster, e(r) is necessary for proper activation of N expression. This is demonstrated by a number of lethal double mutant combinations between e(r) and N alleles. The role of e(r) in mammals is not known, however the human e(r) gene can functionally replace the fruit fly gene. This result argues that the human and fruit fly e(r) genes are performing similar functions.
|Presenter:||Stuart Tsubota (Faculty)|
|Time:||10:45 am (Session II)|