Mitochondria, found in eukaryotic cells, are the powerhouses of the cell. They are responsible for cellular respiration resulting in the production of ATP. Failure to maintain the mitochondrial genome can result in loss of respiration leading to cellular dysfunction. As a result, human diseases such as diabetes mellitus, neurodegenerative disorders, certain cancers, and other age-dependent diseases arise. The lab has developed genetic assays to study genes required to maintain the stability of the mitochondrial genome in the budding yeast, Saccharomyces cerevisiae. This presentation will focus on the genes that belong to the RAD52 epitasis group which is composed of the RAD51, RAD52, RAD54, RAD55, RAD57, RAD59 genes. These genes have been shown to play a role in homologous recombination and double-strand break repair in the nucleus. The lab is interested in determining whether these genes play a role in mitochondrial genome stability.
|Presenter:||Angela Schwingel (Graduate Student)|
|Time:||9 am (Session I)|