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Scholars Day: April 7, 2010

Role of CLU1 in Mitochondrial and Genome Stability

Mitochondria play an essential role in cell survival as the site of respiration and energy production. Unique to the mitochondria is the presence of its own genome distinct from that of nuclear DNA. This genome codes for a variety of proteins required for the respiration process. Mutations in the mitochondrial genome have been implicated in many diseases states such as diabetes, cardiomyopathies, and neurodegenerative disorders. Work in the lab focuses on the effect of the CLU1 gene on mitochondrial genome stability in the budding yeast, Saccharomyces cerevisiae. Loss of Clu1p protein has been shown to alter mitochondrial morphology in budding yeast. The lab will use a variety of genetic assays to determine the effect loss of Clu1p has on respiration proficiency, microsatellite instability, and direct repeat-mediated deletion (DRMD) events. Fluorescence microscopy will also be performed to monitor mitochondrial morphology in the absence of Clu1p.

Presenter: Christina Turcotte (Graduate Student)
Topic: Biology
Location: 101 Edwards
Time: 2:50 pm (Session IV)