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Scholars Day: April 7, 2010

Regulation of Melanin Concentrating Hormone Receptor 1 signaling through ubiquitination.

Melanin concentrating hormone receptor 1 (MCHR1), a G-protein coupled protein receptor, has been implicated in the regulation of appetite and energy homeostasis. Furthering the understanding of MCHR1ís signaling cascade and its regulation is a major focus in the quest to potentially fight obesity. Little is known about the intracellular trafficking of MCHR1. However, it has been hypothesized that MCHR1 covalently links with ubiquitin, which functions as a trafficking controller. Through transfection of BHK-570 cells with VSVg tagged MCHR1 and HA-tagged ubiquitin, co-immunoprecipitation and western blotting techniques, preliminary evidence points to the modification of MCHR1 with ubiquitin. If such modification is determined to be sure, future experiments will attempt to reveal the result of the modified receptor

Presenter: Danielle Feligno (Graduate Student)
Topic: Biology
Location: 101 Edwards
Time: 9:30 am (Session I)