Amino-substituted diaryltellurides and alkylaryltellurides are potent antioxidants, because they readily give up one or two electrons, inhibiting oxidative reactions. This has been demonstrated in a variety of biological and chemical systems. In the literature there are positively charged analogs of vitamin E, a one-electron antioxidant, that have been used to inhibit oxidative damage to mitochondria. This presentation will describe synthetic efforts directed toward the synthesis of positively charged alkylaryltellurides. In collaboration with Dr. Rey Sia in the Department of Biological Sciences, these new antioxidants could be used to better understand the genes involved in repairing oxidative damage in yeast mitochondria.
|Presenter:||Jacqueline Simson (Undergraduate Student)|
|Time:||11:25 am (Session II)|