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Scholars Day 2005, Wednesday, April 13

Role of Clu1p in Mitochondrial Genome Stabiliy in S. cerevisiae

Role of Clu1p in Mitochondrial Genome Stabiliy in S. cerevisiae Crystal R. Allen, Christine E. Hochmuth, and Rey Antonio L. Sia Department of Biological Science, State University of New York-College at Brockport, Brockport, NY 14420 Mitochondrial mutations contribute to many human diseases and therefore are an important research topic. Ilv5p is a gene product that has been shown to have an effect on mitochondrial function. A yeast two hybrid assay was performed with Ilv5p as the “bait” protein. The lab has discovered 45 different protein interactors through this screening process. Clu1 protein (encoded by the CLU1 gene) is one of these proteins. It was previously found to be critical for proper mitochondrial morphology and cytokinesis. Our research using a mutant yeast strain deleted for the CLU1 gene will serve to identify pathways and molecular mechanisms that the Clu1 protein functions in. Initial experiments have shown that loss of CLU1 leads to a decrease in cellular respiration. In addition, direct-repeat recombination in the mitochondrial genome was severely reduced.

Presenters: Crystal Allen (Undergraduate Student)
Christine Hochmuth (Graduate Student)
Topic: Biological Sciences
Location: 123 Hartwell
Time: 1:15 pm (Session III)